David Pitt, M.D.

Assistant Professor, Dept. of Neurology, Division of Neuroimmunology and Multiple Sclerosis


Current Research Description

Multiple sclerosis (MS) is a neurological disease that manifests first as acute, reversible attacks and, in later stages, as progressive and irreversible disability. This laboratory focuses on the pathogenesis of chronic progression in MS. Recent data suggest that with chronicity in MS, microglia become diffusely activated throughout the entire brain. We investigate the impact of this activation on progressive axonal injury and cortical demyelination. In particular, the Pitt lab is interested in the roles of excitotoxicity and oxidative tissue damage in this process. For this, we use brain tissue from MS patients supplemented by experiments in animal models of white matter injury and in cell culture systems. We are also participating in projects defining and improving detection of cortical lesions by magnet resonance imaging.

Areas of Expertise
  • Stress and Neurommunology
  • Neurotrauma, Neurological Disorders, and Gene Therapies
  • MD: Phillips University, Marburg, Germany
  • Postdoctoral Training: Albert Einstein College of Medicine, New York
  • Residency: Albert Einstein College of Medicine, New York

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