Karl Obrietan, Ph.D.
Professor, Dept. of Neuroscience
4036 Graves Hall
333 W. 10th Avenue
Columbus, OH
43210
Areas of Expertise
- Molecular and Cellular Neuroscience
Education
- PhD: Stanford University
- Postdoctoral Training: University of Washington
Current Research Description
Circadian timing
Our lab is interested in characterizing the molecular and cellular events that underlie circadian (24 hr) rhythm generation, and how these rhythms modulate behavior and physiology. Key research themes include:
- Molecular clock timing mechanisms
- Circadian entrainment mechanisms
- Mechanisms of cellular and systems-level circadian clock synchronization
Neuronal signaling and synaptic plasticity
Our lab is interested in understanding how brief bouts of synaptic communication are translated into long-term alterations in neuronal plasticity. Issues related to cellular kinase pathways, inducible gene expression and neuronal morphology are of particular interest to us, as is understanding how these processes underlie complex behavioral processes, including learning and memory. Key research themes include:
- Calcium-activated kinase signaling
- CREB and synaptic physiology
- microRNA and synaptic plasticity
Circadian timing and disorders of the CNS
We are interested in understanding how the disruption of clock timing contributes to neurodegeneration. Current studies of focused on the role of clock dysregulation in Alzheimer’s disease.